Planning

Research phases and timelines

Guiding the process of translating basic neuroscience discoveries into novel clinical treatments will involve three principal research phases:

  1. establishment of animal models for CNS disorders
  2. identification and modulation of pharmacological targets for phenotypic treatment
  3. human clinical trials.

In years 1-2, we will utilize the automated home cage behavioral analysis developed in the NeuroBSIK-MousePhenomics project to identify the best sets of phenotypic traits for each of several established animal models of neurological and psychiatric disorders.

In years 2-3, our focus will be on high-throughput screening of pharmacological interventions to rescue these phenotypic abnormalities.

In years 3-4, armed with the most promising preclinical pharmacological interventions, we will conduct human clinical trials to validate their clinical benefits.

Overall, our approach will be highly integrated across levels, from basic neuroscience to genetics and clinical assessments.